ABSTRACT
Abstract Objective: The objective of this article is to review the most current literature on vaccines, focusing on their safety, immunogenicity, and efficacy in preterm newborns, aiming to improve vaccine coverage in this population. Data source: Most recent scientific publications addressing the immunization of preterm newborns. Data synthesis: Despite its immunological immaturity, vaccination is well tolerated by preterm infants, and protective immune responses are observed, but some studies have shown that preterm infants undergo unjustified delays in their vaccination schedule. Conclusions: Despite being widely recommended, the routine immunization of preterm infants is often delayed, putting this vulnerable population at risk for several diseases, many of which are preventable by immunization. Every effort should be made to develop universal guidelines that define the immunization of preterm infants.
ABSTRACT
OBJECTIVE: The purpose of this study was to determine the levels of Cystatin C in healthy term newborns in the first month of life. INTRODUCTION: Cystatin C may be a suitable marker for determining the glomerular filtration rate because it is not affected by maternal renal function. METHODS: Cohort study. Inclusion: term newborns with appropriate weight; mother without renal failure or drugs that could affect fetal glomerular filtration rate. Exclusion: malformations; hypertension or any condition that could affect glomerular filtration rate. Cystatin C (mg/L)and creatinine (rng/dl) were determined in the mother (Mo) and in the newborn at birth (Day-0), 3rd (Day-3), 7th(Day-7) and 28t>h(Day-28) days. Statistics: one way ANOVA and Pearson's correlation tests. Sample size of 20 subjects for a = 5 percent and a power test = 80 percent (p<0.05). RESULTS: Data from 21 newborns were obtained (mean + standard deviation): MoCystatin C=1.00 ± 0.20; Day-0 Cystatin C 1.70 ± 0.26; Day-3 Cystatin C = 1.51±0.20; Day-7 Cystatin C = 1.54 ± 0.10; Day-28 Cystatin C= 1.51±0.10. MoCystatin C was smaller than Day-0 Cystatin C (p<0.001), while MoCreatinine was not different from Day-0 Creatinine. Cystatin C only decreased from Day-0 to Day-3 (p = 0.004) but newborns Creatinine decreased along the time. Correlations were obtained between MoCystatin C and MoCreatinine (p = 0.012), as well as Day-3 (p = 0.047) and Day-28 (p = 0.022) Cystatin C and Creatinine values. CONCLUSION: Neonatal Cystatin C values were not affected by MoCystatin C and became stable from the 3rd day of life.
Subject(s)
Adult , Female , Humans , Infant, Newborn , Male , Cystatin C/blood , Glomerular Filtration Rate/physiology , Biomarkers/blood , Creatinine/blood , Epidemiologic Methods , Mothers/statistics & numerical dataABSTRACT
A Sociedade de Pediatria de São Paulo, através do seu Departamento de Neonatologia, tem imenso orgulho em colocar à disposição dos pediatras brasileiros e, especificamente, dos neonatologistas, esta obra, que aborda de forma completa e extensiva o recém-nascido de muito baixo peso. Seus capítulos cobrem praticamente todo o curso destas crianças, do nascimento à alta, passando pelo ambiente físico, o suporte nutricional, as intercorrências mais freqüentes, metabólicas ou infecciosas, e a evolução em curto e longo prazos.
Subject(s)
Humans , Infant, Newborn , Enteral Nutrition , Infant, Low Birth Weight , Neonatology , Perinatal CareABSTRACT
Optou-se por avaliar a variacao de peso medio de nascimento dos RNs admitidos no Bercario Anexo a Maternidade do Hospital das Clinicas - FMUSP (BAM-HC-FMUSP), num periodo de 50 anos, aceitando que esse dado possa fornecer informacoes do crescimento intra-uterino e, indiretamente, refletir a qualidade da assistencia perinatal e das condicoes de saude da gestante. METODOS: realizou-se um estudo retrospectivo, avaliando-se os RNs admitidos no...
Subject(s)
Humans , Infant, Newborn , Male , Female , Ethnicity , Infant, Low Birth Weight , Infant, Newborn , Brazil , Infant, Small for Gestational Age , Retrospective StudiesABSTRACT
Os autores apresentam uma revisao das alteracoes placentarias encontradas nas infeccoes por via hematogenica de etiologia viral, especialmente as causadas pelo virus da rubeola, citomegalovirus, hepatites e parvovirus. As alteracoes placentarias, tanto macroscopicas como microscopicas, sao muito semelhantes e independem da etiologia viral. O exame da placenta para determinar a etiologia da infeccao necessita utilizar metodos de isolamento do virus atraves da cultura ou inoculacao , metodos imuno-histoquimicos ou tecnicas de biologia molecular
Subject(s)
Humans , Infant, Newborn , Female , Pregnancy , Pregnancy Complications, Infectious/blood , Communicable Diseases/transmission , Placenta/physiopathology , Infectious Disease Transmission, Vertical , Risk FactorsABSTRACT
A acidemia propionica e uma desordem do metabolismo de acidos organicos caracterizada por um amplo espectro de variacao clinica e laboratorial. Muitas vezes ja se manifesta no periodo neonatal, quando a mortalidade e elevada e as sequelas neurologicas sao graves nos sobreviventes. O caso apresentado refere-se a um recem-nascido do sexo masculino, saudavel ate 49 horas de vida, quando iniciou quadro de recusa alimentar, gemencia e hipotermia. Evoluiu com piora clinica progressiva atingindo estado de neurotoxicidade importante. Desenvolveu acidose metabolica grave e a deteccao de elevados niveis de acido 3-hidroxi-propionico, 2-metil-3-hidroxibutirico e metil-citrico na urina, confirmou o diagnostico de acidemia propionica
Subject(s)
Humans , Female , Infant, Newborn , Male , Adult , Acidosis/diagnosis , Metabolism, Inborn Errors/complications , Acidosis/complications , Genetic Counseling/trendsABSTRACT
Os inibidores da enzima conversora da angiotensina tem sido largamente utilizados para o controle da hipertensao, mas o uso destes durante a gestacao pode provocar obito fetal, retardo de crescimento intra-uterino, sequencia de oligamnio, hipotensao e insuficiencia renal aguda no periodo neonatal e persistencia de canal arterial. O objetivo e chamar a atencao para os possiveis efeitos neonatais do uso desta droga durante a gestacao. Os autores descrevem um caso de uso de captopril durante a gestacao, cujo RN apresentou insuficiencia renal aguda logo apos o nascimento e persistencia de canal arterial necessitando de tratamento clinico...
Subject(s)
Humans , Female , Pregnancy , Infant, Newborn , Acute Kidney Injury/complications , Angiotensin-Converting Enzyme Inhibitors/adverse effects , Hypertension/therapy , Captopril/adverse effects , Fetus , Infant, Newborn , Pregnancy ComplicationsABSTRACT
Os autores descrevem uma criança que apresenta sinais clinicos compativeis com embriopatia por warfarin. Os principais achados säo facies peculiar com hipoplasia nasal, membros encurtados e presença de calcificaçöes peri-epifisárias no estudo radiológico. A patogenese da embriopatia e recomendaçöes terapeuticas para as mulheres que necessitam fazer uso de anticoagulante oral durante a gestaçäo, säo discutidas